Work

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Year: 2020

Type: review

Abstract: Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer's disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.

Source: Molecules

DOI: 10.3390/molecules25214901

Authors: Seydou Ka, Manoj Koirala, Natacha Mérindol, Isabel Desgagné-Penix

Institution: Université du Québec à Trois-Rivières

Language: English

Topic: Chemical synthesis and alkaloids

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,112

Funder: Canada Research Chairs