COVID-19 in children across three Asian cosmopolitan regions
Year: 2020
Type: article
Study design: Observational Study
Abstract: As another wave of COVID-19 outbreak has approached in July 2020, a larger scale COVID-19 pediatric Asian cohort summarizing the clinical observations is warranted. Children confirmed with COVID-19 infection from the Republic of Korea, the Hong Kong Special Administrative Region (HKSAR) and Wuhan, China, during their first waves of local outbreaks were included. Their clinical characteristics and the temporal sequences of the first waves of local paediatric outbreaks were compared. Four hundred and twenty three children with COVID-19 were analyzed. Wuhan had the earliest peak, followed by Korea and HKSAR. Compared with Korea and Wuhan, patients in HKSAR were significantly older (mean age: 12.9 vs. 10.8 vs. 6.6 years, p < 0.001, respectively) and had more imported cases (87.5% vs. 16.5% vs. 0%, p < 0.001, respectively). The imported cases were also older (13.4 vs. 7.6 years, p < 0.001). More cases in HKSAR were asymptomatic compared to Korea and Wuhan (45.5% vs. 22.0% vs. 20.9%, p < 0.001, respectively), and significantly more patients from Wuhan developed fever (40.6% vs. 29.7% vs. 21.6%, p=0.003, respectively). There were significantly less imported cases than domestic cases developing fever after adjusting for age and region of origin (p = 0.046). 5.4% to 10.8% of patients reported anosmia and ageusia. None developed pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PMIS-TS). In general, adolescents were more likely to be asymptomatic and less likely to develop fever, but required longer hospital stays. In conclusion, majority patients in this pediatric Asian cohort had a mild disease. None developed PIMS-TS. Their clinical characteristics were influenced by travel history and age.
Source: Emerging Microbes & Infections
Authors: Gilbert T. Chua, Xiaoli Xiong, Eun Hwa Choi, Mi Seon Han, Sung Hee Chang, Byoung Lo Jin, Eun Joo Lee, Baek Nam Kim, Min Kyoung Kim, Kihyun Doo, Ju Hee Seo, Yae Jean Kim, Yeo Jin Kim, Ji Young Park, Sun Bok Suh, Hyunju Lee, Eun Young Cho, Dong Hyun Kim, Jong Min Kim, Hye Young Kim, Su Eun Park, Joon Kee Lee, Dae Sun Jo, Seung Man Cho, Jae Hong Choi, Kyo Jin Jo, Young June Choe, Ki Hwan Kim, Shuiqing Chi, Shao-tao Tang, Huan Qin, Li Shan Zhou, Peng Chen, Joshua Sung Chih Wong, Kate Ching Ching Chan, Felix Yat Sun Yau, Shu Yan Lam, Calvin Chit Kwong Chow, Tak Wai Wong, Victor Chi-man Chan, Grace Wing Kit Poon, Chun Bong Chow, Wilfred H. S. Wong, Yu Lung Lau, Godfrey Chi Fung Chan, Celine S. L. Chui, Xue Li, Marco Hok Kung Ho, Ian C. K. Wong, Paul Kwong Hang Tam, Kelvin K. W. To, Jong Hyun Kim, Patrick Ip, Mike Yat Wah Kwan
Institutions: University of Hong Kong, Wuhan Children's Hospital, Huazhong University of Science and Technology, Seoul National University, Seoul Metropolitan Government, SNUH SMG-SNU Boramae Medical Center, Seoul Medical Center, Hongseong Medical Center, Seongnam Citizens Medical Center, Gyeonggi Provincal Medical Center Ansung Hospital, Gyeonggi Provincal Medical Center Icheon Hospital, Dankook University Hospital, Samsung Medical Center, Gyeongsangnam-do Masan Medical Center, Sungkyunkwan University, Chung-Ang University Hospital, Busan Medical Center, Seoul National University Bundang Hospital, Chungnam National University, Chungnam National University Hospital, Inha University, Inha University Hospital, Myongji Hospital, Catholic University of Korea, Pusan National University Hospital, Pusan National University Children's Hospital, Chungbuk National University, Chungbuk National University Hospital, Jeonbuk National University Hospital, Jeonbuk National University, Dongguk University, Dongguk University Gyeongju Hospital, Jeju National University Hospital, Jeju National University, Hallym University, The Catholic University of Korea Incheon St. Mary's Hospital, Wuhan Union Hospital, Princess Margaret Cancer Centre, Princess Margaret Hospital, Chinese University of Hong Kong, Queen Elizabeth Hospital, Tuen Mun Hospital, United Christian Hospital, Alice Ho Miu Ling Nethersole Hospital, Pamela Youde Nethersole Eastern Hospital, Queen Mary Hospital, UCL School of Pharmacy, University College London, The Catholic University of Korea St. Vincent's Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,643
OpenAlex ID: W3095459135