COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms
Year: 2020
Type: article
Abstract: Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and poses a huge threat to human health. Besides common respiratory symptoms, some patients with COVID-19 experience gastrointestinal symptoms, such as diarrhea, nausea, vomiting, and loss of appetite. SARS-CoV-2 might infect the gastrointestinal tract through its viral receptor angiotensin-converting enzyme 2 (ACE2) and there is increasing evidence of a possible fecal-oral transmission route. In addition, there exist multiple abnormalities in liver enzymes. COVID-19-related liver injury may be due to drug-induced liver injury, systemic inflammatory reaction, and hypoxia-ischemia reperfusion injury. The direct toxic attack of SARS-CoV-2 on the liver is still questionable. This review highlights the manifestations and potential mechanisms of gastrointestinal and hepatic injuries in COVID-19 to raise awareness of digestive system injury in COVID-19.
Institutions: Shanghai Medical College of Fudan University, Henan University, Fudan University, Southwest Medical University, Henan University Huaihe Hospital and Huaihe Clinical Institute, Fudan University Shanghai Cancer Center, Zhongshan Hospital, Shanghai Jiao Tong University, Shanghai First People's Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,680
Award: G1303021332
OpenAlex ID: W3095861979