Year: 2020
Type: article
Abstract: Significance Production of IL-1β is an essential component of the inflammatory response and host defense. IL-1β secretion is dependent on the activation of an intracellular platform termed inflammasome. The initial inflammatory signals that drive inflammasome activation remains elusive. Here, we show that the bioactive lipid leukotriene B 4 enhances both transcriptional and posttranscriptional programs that activate the inflammasome in vivo and in vitro. We identified critical signaling programs required for inflammasome assembly, IL-1β secretion, and its consequences in skin host defense. Our data also suggest that the prevention of LTB 4 actions might be an important therapeutic strategy to prevent IL-1β–dependent inflammatory diseases by inhibiting both first and second signals necessary for inflammasome activation.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: Immunological Mechanisms of Disease Training Program, G29316538, G295657101, Phosphatase and tensin homolog PTEN actions in polymicrobial sepsis, G4453313174, G5802044267, Mechanisms underlying poor skin host defense in diabetic conditions, Prostaglandin E2 Actions and Enhanced Susceptibility to Skin Infection in Diabetic Mice, G8417734172, Immunology and Infectious Diseases Training Program
OpenAlex ID: W3098806366