Effect of ERCC2 rs13181 and rs1799793 polymorphisms and environmental factors on the prognosis of patients with lung cancer.
Year: 2020
Type: article
Study design: Observational Study
Abstract: PURPOSE: ) genes (rs13181 and rs1799793) and the prognosis of patients with lung cancer. METHODS: genotype was analyzed using a multivariate Cox proportional hazards model adjusted for multiple potential confounders. RESULTS: rs13181 T>G significantly increased the risk of death (adjust hazard ratio (HR) = 1.29, 95% CI: 1.06-1.56, P = 0.009). Patients with the rs13181 TG genotype (adjust HR = 1.34, 95% CI: 1.08-1.65, P = 0.007) and rs13181 dominant mode TG+GG (adjust HR = 1.33, 95% CI: 1.08-1.63, P = 0.007) had significantly worse overall survival. Moreover, stratified analyses showed that patients with the TG and TG+GG rs13181 genotypes who were male, elderly (≥60 years), had a history of smoking, or without family history of malignant tumors had a significantly increased risk of death. In patients with adenocarcinoma lung cancer (ADC), the rs1799793 genotype CT (adjust HR = 1.49, 95% CI: 1.06-2.09, P = 0.023) and dominant model CT+TT (adjust HR = 1.45, 95% CI = 1.04-2.02, P = 0.027) were associated with an increased risk of death. CONCLUSION: rs13181 and rs1799793 SNPs may be significant prognostic factors for the risk of death among patients with lung cancer.
Source: PubMed
Authors: Haorui Zhang, Yutao Li, Shicheng Guo, Yi Wang, Haijian Wang, Daru Lu, Jiucun Wang, Li Jin, Gengxi Jiang, Junjie Wu, Yiping Han, Juhong Li
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3103250686