Highlight of severe acute respiratory syndrome coronavirus-2 vaccine development against COVID-19 pandemic
Year: 2020
Type: review
Abstract: The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has brought an unprecedented impact upon the global economy and public health. Although the SARS-CoV-2 virology has been gradually investigated, measures to combat this new threat in public health are still absent. To date, no certificated drug or vaccine has been developed for the treatment or prevention of coronavirus disease Extensive researches and international coordination has been conducted to rapidly develop novel vaccines against SARS-CoV-2 pandemic. Several major breakthroughs have been made through the identification of the genetic sequence and structural/non-structural proteins of SARS-CoV-2, which enabled the development of RNA-, DNA-based vaccines, subunit vaccines, and attenuated viral vaccines. In this review article, we present an overview of the recent advances of SARS-CoV-2 vaccines and the challenges that may be encountered in the development process, highlighting the advantages and disadvantages of these approaches that may help in effectively countering COVID-19.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G2434625447, Advanced Translation of Cellular Reprogramming Technologies in Regenerative Medicine( I ), G4250672045, Novel Bioengineering and Technological Approaches to Solve Three Major Health Problems in Taiwan( III ), Investigating the Role of Mrna Methylation Modification in Oxidative Stress-Induced Retinal Degenerative Diseases
OpenAlex ID: W3106445801