Synthesis of 1ʹ-acetoxychavicol acetate (ACA) analogues and their inhibitory activities against methicillin-resistant Staphylococcus aureus
Year: 2020
Type: article
Abstract: A series of 1ʹ-acetoxychavicol acetate analogues were synthesised and evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) using broth microdilution technique. The minimum inhibitory concentration (MIC) was used to determine whether the compounds had potential as inhibitory agents against the MRSA ATCC 43300, and the compounds with antimicrobial potential (<2000 μg ml–1) were tested for minimum bactericidal concentration (MBC). Based on this assay, compound 1 exhibited potent antimicrobial activity with MIC value of 250 μg ml–1. Meanwhile, compounds 2 and 13 showed the moderate activity with MIC values of 500 μg ml–1, respectively.
Source: Journal of Physical Science
Authors: Universiti Sains Malaysia, Nursyazwani Anuar, Mohamad Nurul Azmi Mohamad Taib, Universiti Sains Malaysia, Khayriyyah Mohd Hanafiah, Universiti Sains Malaysia, Aemen Ali Kudayr Al Shammary, Universiti Sains Malaysia, Nur Shazieyatul Nadiah Shalan, Universiti Sains Malaysia, Siti Nur Izaty Che Humaidi, Universiti Sains Malaysia, Khalijah Awang
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W3107914937