Year: 2020
Type: article
Abstract: The implementation of continuous flow technology is critical towards enhancing the application of photochemical reactions for industrial process development. However, there are significant time and resource constraints associated with translating discovery scale vial-based batch reactions to continuous flow scale-up conditions. Herein we report the development of a droplet microfluidic platform, which enables high-throughput reaction discovery in flow to generate pharmaceutically relevant compound libraries. This platform allows for enhanced material efficiency, as reactions can be performed on picomole scale. Furthermore, high-throughput data collection via on-line ESI mass spectrometry facilitates the rapid analysis of individual, nanoliter-sized reaction droplets at acquisition rates of 0.3 samples/s. We envision this high-throughput screening platform to expand upon the robust capabilities and impact of photochemical reactions in drug discovery and development.
Source: Nature Communications
Institution: University of Michigan
Language: English
Subfield: Fluid Flow and Transfer Processes
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $5,380
Awards: G1323680257, G262919552, GOALI: Biocatalysis Development using High-throughput Droplet Microfluidics and Mass Spectrometry, G4803345525, G6754577922, Graduate Research Fellowship Program (GRFP), G7454331993, Redox catalysis strategies for synthesis, G8654503962, G8883008220, G8914536270, G895164487
OpenAlex ID: W3108955872