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Research Article Anti-inflammatory and anti-allergic activity of the methanolic extract from Annona sylvatica (Annonaceae)

Year: 2020
Type: article
Abstract: induced paw edema.Moreover, in the OVA-induced allergic lung inflammation model, oral treatment with MEAS (150 mg/kg) significantly inhibited neutrophil, eosinophil, and mononuclear cells migration to the lung.Pretreatment of neutrophils with MEAS (3, 150, 300 µg/mL) significantly reduced neutrophil chemotaxis induced by N-Formyl-Met-Leu-Ph (fMLP) and complement 5a (C5a, in a concentration-dependent manner.We conclude that A. sylvatica has antiinflammatory and anti-allergic properties.Flavonoids and acetogenins, compounds found in the MEAS, could be responsible for these antiinflammatory and anti-allergic effects.
DOI: 10.4238/gmr18661
Authors: M. Andrade-Silva, S.C. Cavalher-Machado, A.S.N. Formagio, R.S. Maris, O.M. de Lima Junior, S.B.V. de Mello, M.G.M.O. Henriques, A.C. Arena, C.A.L. Kassuya
Institutions: Universidade Federal da Grande Dourados, Universidade Nove de Julho, Instituto de Tecnologia em Fármacos, Fundação Oswaldo Cruz, Universidade de São Paulo, Universidade Estadual Paulista (Unesp)
Language: English
Subfield: Biochemistry
Open Access status: bronze
OpenAlex ID: W3109323902
FWCI: 0.102
Cites: 26
Cited by: 4
Related to: 10