Work

Divergent effects of peripheral and global neuropeptide Y deletion.

Year: 2020

Type: article

Abstract: OBJECTIVES: model. METHODS: model. We evaluated body weight, adiposity and functionally assessed the feeding response of NPY neurons to determine whether central NPY signaling was altered by Prx1cre. RESULTS: mice showed no difference, demonstrating that local mesenchymal-derived NPY does not influence adiposity. CONCLUSION: NPY mediates both positive and negative effects on bone mass via separate regulatory pathways. Deletion of mesenchymal-derived NPY had a positive effect on bone mass.

Source: PubMed

Authors: Natalie K Y Wee, Ivana Vrhovac Madunic, Tonci Ivanisevic, Benjamin P Sinder, Ivo Kalajzic

Institutions: UConn Health, Institute for Medical Research and Occupational Health, University of Oxford

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1393856290, Growth Factor Based on Enhancement of Bone Repair, G9000092582, Notch signaling and Bone Fracture Healing