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Time for enhancing government-led primary prevention of cervical cancer

Year: 2020
Type: editorial
Abstract: ejgo.orgCervical cancer is a preventable disease.Lei et al. [1] recently demonstrated using the Swedish nationwide registry that human papillomavirus (HPV) vaccines protected not only precancerous cervical lesions but also invasive cervical cancers.In this study, the risk of cervical cancer among women who had been vaccinated <17 years of age was 88% lower than the unvaccinated population.This effective vaccination results in a survival benefit when 'herd immunity' is achieved through high vaccination coverage in a population.One systematic review and meta-analysis by Drolet et al. [2] found that unvaccinated persons would indirectly benefit from HPV vaccination if vaccination coverage of girls and women in a population exceeds 50%.Vaccine coverage of the study of Lei et al. [1] in Sweden was 83.9% in the 2002 birth cohort and as high as 83.3%-97.7% in Australia where cervical cancer incidence continually declined over the years of vaccination [3,4].This critical role of high vaccine coverage rates in reduction of cervical cancer incidence suggest that the HPV vaccination program must be scaled to national levels.The World Health Organization (WHO) reported countries with HPV vaccines in the National Immunization Program (NIP) (Fig. 1), which showed that HPV vaccine coverages of most Asian countries was very low [5].Whereas 83.4% and 62.5% of 15-year-old girls in Malaysia and Korea completed HPV vaccinations in 2018, respectively, vaccine coverage in Indonesia, the Philippines and Singapore ranged from just 0.1% to 0.7%.In Thailand, 91% of 12,500 girls aged 11 years in Ayutthaya province received at least 2 doses of HPV vaccine within a pilot vaccination program from 2014 to 2016, with excellent safety and high acceptability.Thereafter, HPV vaccination gradually expanded to the national level in
DOI: 10.3802/jgo.2021.32.e12
Authors: Kyung-Jin Min, Dong Hoon Suh, Tsukasa Baba, Xiaojun Chen, Jae-Weon Kim, Yusuke Kobayashi, Janice Kwon, Myong Cheol Lim, Jung-Yun Lee, Satoru Nagase, Jeong-Yeol Park, Siriwan Tangjitgamol, Hidemichi Watari
Institutions: Korea University, Seoul National University, Seoul National University Bundang Hospital, Iwate Medical University, Obstetrics and Gynecology Hospital of Fudan University, Keio University, University of British Columbia, National Cancer Center, Yonsei University, Yonsei University Health System, Yamagata University, Asan Medical Center, University of Ulsan, Navamindradhiraj University, Vajira Hospital, MedPark Hospital, Hokkaido University
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: diamond
OpenAlex ID: W3111661845
Cites: 15
Cited by: 14
Related to: 10