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A Mouse Model for Microbeam Radiation Therapy of the Lung

Year: 2020
Type: article
Abstract: PURPOSE: Radiation therapy is an important treatment component for patients with lung cancer. However, the survival time gained with clinical radiation therapy techniques is relatively short. Data from preclinical experiments suggest that synchrotron microbeam radiation therapy could be much better suited to control malignant brain tumors than current clinical concepts of radiation therapy. Even at peak doses of several hundred gray, the extent of functional deficits is low. METHODS AND MATERIALS: We have developed the first mouse model to study the effects of microbeam irradiation in lung tissue. RESULTS: Up to peak doses of 400 Gy, no acute adverse effects were seen. CONCLUSION: This model is well suited to explore the potential of microbeam radiation therapy in the treatment of lung cancer and the response of normal lung tissue and organs at risk.
DOI: 10.1016/j.ijrobp.2020.12.030
Authors: Elisabeth Schültke, Sam Bayat, Stefan Bartzsch, Elke Bräuer-Krisch, Valentin Djonov, Stefan Fiedler, Cristian Fernandez-Palomo, Felix Jaekel, Paolo Pellicioli, Verdiana Trappetti, Guido Hildebrandt
Institutions: Universitätsmedizin Rostock, Inserm, Centre Hospitalier Universitaire de Grenoble, Université Grenoble Alpes, Helmholtz Munich, Technical University of Munich, European Synchrotron Radiation Facility, University of Bern, European Molecular Biology Laboratory
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $2,500
OpenAlex ID: W3114986586
FWCI: 2.249
Cites: 17
Cited by: 25
Related to: 10