Work

New 1,3,4-oxadiazole Based Schiff Base Derivatives: Synthesis, Characterization and Antibacterial Activity Along With in Silico Studies

Year: 2021

Type: article

Abstract: A series of novel 1,3,4-oxadiazole based Schiff base derivatives were designed and synthesized using the efficient strategy with excellent yields. Synthesized molecules evaluated in vitro antibacterial studies in contradiction of microorganisms, namely Escherichia coli , Klebsiella pneumoniae, Bacillus subtilis , and Bacillus megaterium . The bioassay result revealed that most of tested compounds good to moderate inhibition against microorganisms. Some among them show excellent inhibitory effects towards the Gram-positive and Gram-negative bacteria. Besides, the drug-likeness, lipophilicity and cytotoxicity.

Source: European Chemical Bulletin

DOI: 10.17628/ecb.2021.10.139-146

Authors: Jaydeep Lalpara, Sanjay Hadiyal, Jayesh Dhalani, G. G. Dubal

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $107

OpenAlex ID: W3125878476

FWCI: 0.288

Cites:

Cited by: 3

Related to: 10