Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Mobility disability and parkinsonism are associated with decreased survival in older adults. This study examined the transition from no motor impairment to mobility disability and parkinsonism and their associations with death. METHODS: 867 community-dwelling older adults without mobility disability or parkinsonism at baseline were examined annually. Mobility disability was based on annual measured gait speed. Parkinsonism was based on the annual assessment of 26 items from the motor portion of the Unified Parkinson's Disease Rating Scale. A multistate Cox model simultaneously examined the incidences of mobility disability and parkinsonism and their associations with death. RESULTS: Average age at baseline was 75 years old and 318 (37%) died during 10 years of follow-up. Mobility disability was almost 2-fold more common than parkinsonism. Some participants developed mobility disability alone (42%), or parkinsonism alone (5%), while many developed both (41%). Individuals with mobility disability or parkinsonism alone had an increased risk of death, but their risk was less than the risk in individuals with both impairments. The risk of death did not depend on the order in which impairments occurred. CONCLUSION: The varied patterns of transitions from no motor impairment to motor impairment highlights the heterogeneity of late-life motor impairment and its contribution to survival. Further studies are needed to elucidate the underlying biology of these different transitions and how they might impact survival.
Source: PLoS ONE
Institution: Rush University Medical Center
Language: English
Field: Health Professions
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,749
Awards: Brain and Spinal Cord Microvascular Pathology in Late-Life Motor Impairment, Epidemiologic Study of Neural Reserve and Neurobiology of Aging, Impaired Gait in Older Adults: Pathologies of Alzheimer's disease and Related Disorders, Racial Differences in Late-Life Cognitive decline and risk of Alzheimer's Disease, Risk Factors, Pathology, and Clinical Expressions of AD, The Clinical Profile of Parkinson's Disease (PD) Pathology, Rush Alzheimer's Disease Core Center, G7814573875
OpenAlex ID: W3126790438