Gold/Polyoxometalate Core/Shell Nanoparticles for Combined Chemotherapy–Photothermal Cancer Therapy
Year: 2021
Type: article
Abstract: We designed monodisperse and perfectly shaped core/shell [email protected] 4 Zol 2 Mn nanohybrids consisting of gold nanoparticles (AuNPs) functionalized by an antitumoral polyoxometalate (POM) incorporating the biologically active zoledronate ligand. After incubation, the nanoparticles were readily confined in the endosomal compartments of PC3 human prostate adenocarcinoma cells. Under photothermal treatment, the metabolic activity drastically decreased at concentrations where the nanohybrids exhibited no anticancer activity in the dark, and almost all cancer cells were killed at concentrations at which zoledronate alone was totally inactive. This study evidences for the first time that AuNPs capped by POMs can represent excellent candidates for combined chemotherapy and photothermal cancer therapy.
Source: ACS Applied Nano Materials
Institutions: Centre National de la Recherche Scientifique, Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Sorbonne Université, Laboratoire de Réactivité de Surface, Institut Lavoisier de Versailles, Université Paris Cité, Université Paris Sciences et Lettres, Laboratoire Matière et Systèmes Complexes, Physique des Cellules et Cancers, Institut Curie
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3130136682