Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from Codium tomentosum
Year: 2021
Type: article
Abstract: Parkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and is characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it is crucial to find new therapeutic options to fight the neurodegenerative process, which may arise from marine resources. Accordingly, the goal of the present work was to evaluate the ability of the monoterpenoid lactone Loliolide, isolated from the green seaweed Codium tomentosum, to prevent neurological cell death mediated by the neurotoxin 6-hydroxydopamine (6-OHDA) on SH-SY5Y cells and their anti-inflammatory effects in RAW 264.7 macrophages. Loliolide was obtained from the diethyl ether extract, purified through column chromatography and identified by NMR spectroscopy. The neuroprotective effects were evaluated by the MTT method. Cells’ exposure to 6-OHDA in the presence of Loliolide led to an increase of cells’ viability in 40%, and this effect was mediated by mitochondrial protection, reduction of oxidative stress condition and apoptosis, and inhibition of the NF-kB pathway. Additionally, Loliolide also suppressed nitric oxide production and inhibited the production of TNF-α and IL-6 pro-inflammatory cytokines. The results suggest that Loliolide can inspire the development of new neuroprotective therapeutic agents and thus, more detailed studies should be considered to validate its pharmacological potential.
DOI: 10.3390/ijms22041888
Language: English
Subfield: Aquatic Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,160
Awards: G1167214205, G121659266, G2734280741, G274581676, G3400227948, Biomoléculas para a Saúde: absorção de colesterol, e expressão das suas proteínas transportadoras, interacção com fármacos, G3785917697, G3811734797, G3953973867, G4520493619, G4724859719, ONCOLOGIA DE PRECISÃO: TERAPIAS E TECNOLOGIAS INOVADORAS, Instituto de Biosistemas & Ciências Integrativas, G5454278309, G5677667711, G5689831786, G5749655397, G5916039821, Neuroprotective effects of molecules isolated from Bifurcaria bifurcata and Codium tomentosum in an in vitro and in vivo Parkinson Disease model., G6106829206, Instituto de Biosistemas & Ciências Integrativas, G6737367084, SmartBioR Valorização Inteligente de Recursos Biológicos Marinhos Endógenos num Clima em Mudança, G686143194, Criar oportunidades a partir de polissacarídeos sulfatados isolados de macroalgas para aplicação terapêutica, G7341544869, G7651279925, G7965899483, G8034029280, G8581589583, G895802915, G915365265
OpenAlex ID: W3130184083