Year: 2021
Type: article
Study design: Observational Study
Abstract: We sought to assess the association between common antihypertensive drugs and the risk of incident cancer in treated hypertensive patients. Using the Korean National Health Insurance Service database, the risk of cancer incidence was analyzed in patients with hypertension who were initially free of cancer and used the following antihypertensive drug classes: Angiotensin-converting enzyme inhibitors (ACEIs); angiotensin receptor blockers (ARBs); beta blockers (BBs); calcium channel blockers (CCBs); and diuretics. During a median follow-up of 8.6 years, there were 4513 (6.4%) overall cancer incidences from an initial 70,549 individuals taking antihypertensive drugs. ARB use was associated with a decreased risk for overall cancer in a crude model (hazard ratio (HR): 0.744, 95% confidence interval (CI): 0.696-0.794) and a fully adjusted model (HR: 0.833, 95% CI: 0.775-0.896) compared with individuals not taking ARBs. Other antihypertensive drugs, including ACEIs, CCBs, BBs, and diuretics, did not show significant associations with incident cancer overall. The long-term use of ARBs was significantly associated with a reduced risk of incident cancer over time. The users of common antihypertensive medications were not associated with an increased risk of cancer overall compared to users of other classes of antihypertensive drugs. ARB use was independently associated with a decreased risk of cancer overall compared to other antihypertensive drugs.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm10040771
Authors: In-Jeong Cho, Jeong-Hun Shin, Mi-Hyang Jung, Chae Young Kang, Jinseub Hwang, Chang Hee Kwon, Woohyeun Kim, Dae-Hee Kim, Chan Joo Lee, Si-Hyuck Kang, Ju-Hee Lee, Hack-Lyoung Kim, Hyue Mee Kim, Iksung Cho, Hae-Young Lee, Wook-Jin Chung, Sang-Hyun Ihm, Kwang Il Kim, Eun Joo Cho, Il-Suk Sohn, Sungha Park, Jinho Shin, Sung Kee Ryu, Jang Young Kim, Seok-Min Kang, Myeong-Chan Cho, Wook Bum Pyun, Ki-Chul Sung
Institutions: Ewha Womans University, Yonsei University, Severance Hospital, Yonsei University Health System, Ewha Womans University Seoul Hospital, Hanyang University, Hallym University, Hallym University Dongtan Sacred Heart Hospital, Daegu University, Konkuk University, Konkuk University Medical Center, Asan Medical Center, University of Ulsan, Seoul National University, Seoul National University Bundang Hospital, Chungbuk National University, Chungbuk National University Hospital, SNUH SMG-SNU Boramae Medical Center, Chung-Ang University Hospital, Chung-Ang University, Seoul National University Hospital, Gachon University Gil Medical Center, The Catholic University of Korea Bucheon St. Mary's Hospital, Catholic University of Korea, The Catholic University of Korea Yeouido St. Mary's Hospital, Kyung Hee University, Kyung Hee University Hospital at Gangdong, Eulji Medical Center, Kangbuk Samsung Hospital, Sungkyunkwan University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,376
OpenAlex ID: W3131963203