Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera
Year: 2021
Type: article
Abstract: The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK, B.1.1.7; South Africa, B.1.351; and Brazil, P.1. These variants have multiple changes in the immunodominant spike protein that facilitates viral cell entry via the angiotensin-converting enzyme-2 (ACE2) receptor. Mutations in the receptor recognition site on the spike are of great concern for their potential for immune escape. Here, we describe a structure-function analysis of B.1.351 using a large cohort of convalescent and vaccinee serum samples. The receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes. In a number of cases, it would appear that convalescent and some vaccine serum offers limited protection against this variant.
Source: Cell
Authors: Daming Zhou, Wanwisa Dejnirattisai, Piyada Supasa, Chang Liu, Alexander J. Mentzer, Helen M. Ginn, Yuguang Zhao, Helen M.E. Duyvesteyn, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Guido C. Paesen, Cesar Lopez-Camacho, Jose Slon-Campos, Bassam Hallis, Naomi Coombes, Kevin Bewley, Sue Charlton, Thomas S. Walter, Donal Skelly, Sheila F. Lumley, Christina Dold, Robert Levin, Tao Dong, Andrew J. Pollard, Julian C. Knight, Derrick Crook, Teresa Lambe, Elizabeth Clutterbuck, Sagida Bibi, Amy Flaxman, Mustapha Bittaye, Sandra Belij-Rammerstorfer, Sarah Gilbert, William James, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton
Institutions: Centre for Human Genetics, University of Oxford, Oxford University Hospitals NHS Trust, Instruct-ERIC, Public Health England, Medawar Building for Pathogen Research, NIHR Oxford Biomedical Research Centre, Worthing Hospital, University Hospitals Sussex NHS Foundation Trust, MRC Weatherall Institute of Molecular Medicine, MRC Human Immunology Unit, Jenner Institute, Mahidol Oxford Tropical Medicine Research Unit, Siriraj Hospital, Mahidol University, Diamond Light Source
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $9,900
Funders: Wellcome Trust, UK Research and Innovation, Coalition for Epidemic Preparedness Innovations, Cancer Research UK, National Institute for Health and Care Research, Department of Health and Social Care, Public Health England, Chinese Academy of Medical Sciences, China Academy of Chinese Medical Sciences, National Institutes of Health, Medical Research Council, NIHR Oxford Biomedical Research Centre
Awards: G1068721202, Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics, G2567570596, Increasing the flavivirus envelope glycoprotein dimer stability to elicit potent and broadly neutralizing antibody responses, G3276968844, G3387191942, G3733753208, G3827460392, G3873106536, G4202993990, G5155016511, Structural Studies on Viruses, Viral Proteins and Cell Interactions, Characterising extreme innate immune response phenotypes informative for disease using a functional genomics approach, G5846212695, G6444908106, Improved control of endemic foot-and-mouth disease by development of virus like particle vaccines, G6928973985, Studies of immunopathogenesis in dengue virus infection., G7965603915, NIHR Senior Investigator Award, Function of novel human T cell subsets in host defence, Covid-19 Vaccine, NIHR Senior Investigator Award, Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics.
OpenAlex ID: W3131995220