Antiviral Activity of Different Extracts of Standardized Propolis Preparations against HSV
Year: 2019
Type: article
Abstract: BACKGROUND: Viral infections are among the most common problems in health-care practice. Natural products offer great promise as potentially effective antiviral drugs. Propolis is a honeybee product with biological properties and therapeutic applications. We aimed to investigate the antiviral activity of different extracts of Standardized Propolis Preparations (M.E.D.®) with glycol, ethanol, glycerol and soya oil, against herpes simplex type-1 (HSV-1) and type 2 (HSV-2) viruses. METHODS: ) was determined as a parameter to indicate the in vitro antiviral activity of the extracts compared with acyclovir as the control. RESULTS: SI values of glycol, ethanol, glycerol, soya oil extracts and acyclovir were determined as 6.8, 4.1, 2.2, 3.3 and 6.3 against HSV-1, and as 6.4, 7.7, 1.9, 4.2 and 2.9 against HSV-2, respectively. Glycolic propolis extract was found to possess a greater antiviral activity than acyclovir for both HSV-1 and 2, while glycolic, ethanolic and soya oil preparations were found to have more significant activity than acyclovir for HSV-2. CONCLUSIONS: It was determined that standardized propolis preparations have antiviral bioactivity against HSV.
Source: Antiviral Therapy
DOI: 10.3851/imp3383
Language: English
Subfield: Insect Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3132496772