Work

Standardization of experimental model regarding star fruit intoxication in Wistar rats suffering with nephropathy

Year: 2021

Type: article

Abstract: PURPOSE: To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication. METHODS: Twenty-five Wistar rats were used and divided into five groups: Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice. RESULTS: To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication. CONCLUSIONS: The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process.

Source: Acta Cirúrgica Brasileira

DOI: 10.1590/acb360204

Authors: Layla Alves Rodrigues da Silva, Renato Figueiredo Santana, Eduardo Achar, Gerson Ballester, Sandra Regina Mota Ortiz, Marcelo Augusto Fontenelle Ribeiro Junior

Institutions: Instituto de Assistência Médica ao Servidor Público Estadual, Universidade Cidade de São Paulo, Universidade São Judas Tadeu, Pontifícia Universidade Católica de São Paulo

Language: English

Topic: Epilepsy research and treatment

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500