Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries
Year: 2021
Type: article
Abstract: , which causes impaired protein secretion and type I collagen fibrillogenesis, is associated with tendon and ligament injuries in patients. Together, our results demonstrate that SPARC is a key extracellular matrix protein essential for load-induced tendon tissue maturation and homeostasis.
Source: Science Translational Medicine
Authors: Tao Wang, Andrea Wagner, Renate Gehwolf, Wenjin Yan, Fabian S. Passini, Christine Thien, Nadja Weissenbacher, Zhen Lin, Christine Lehner, Huajian Teng, Claudia Wittner, Qiujian Zheng, Jin Dai, Ming Ni, Allan Wang, John Papadimitriou, Toby Leys, Rocky S. Tuan, Sasha Senck, Jess G. Snedeker, Herbert Tempfer, Qing Jiang, Ming H. Zheng, Andreas Traweger
Institutions: The University of Western Australia, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Paracelsus Medical University, Austrian Cluster for Tissue Regeneration, Nanjing Drum Tower Hospital, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, University of Zurich, ETH Zurich, Universitätsklinik Balgrist, Institute for Biomechanics, Model Animal Research Center, University of Applied Sciences Upper Austria, Chinese People's Liberation Army, Pathwest Laboratory Medicine, University of Pittsburgh, Chinese University of Hong Kong, Perron Institute for Neurological and Translational Science
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3133026432