Work

Guanidinium and Phosphonium Scaffolds Loaded with Silver Nanoparticles: Synthesis, Characterization, In Vitro Assessment of the Antibacterial Potential and Toxicity

Year: 2021

Type: article

Abstract: New silver nanocomposites based on polysulfones of 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride [poly(AGC-SO2)], tris(diethylamino)diallylaminophosphonium tetrafluoroborate [poly(DAAP-BF4-SO2)] and chloride [poly(DAAP-Cl-SO2)] have been developed. UV- spectroscopy, SEM and XRD techniques were used to characterize the formation of silver nanoparticles in copolymers. Antibacterial action of new silver nanocomposites on S. epidermidis 33 and Escherichia coli (planktonic cells and biofilms) was studied. The silver nanocomposites strongly inhibited biofilms formation of S. epidermidis 33 and Escherichia coli. The silver nanocomposites based on phosphonium polysulfones have a significant cytotoxic activity against RD and MS line cells.

Source: Journal of Inorganic and Organometallic Polymers and Materials

DOI: 10.1007/s10904-021-01941-2

Authors: Marina Gorbunova, Larisa Lemkina, Anton Nechaev

Institutions: Russian Academy of Sciences, Institute of Technical Chemistry, Institute of Ecology and Genetics of Microorganisms

Language: English

Topic: Nanoparticles: synthesis and applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Russian Foundation for Basic Research