Work

Potential Inhibition by Phaleria macrocarpa Leaves Ethanol Extract on Ki-67 Expression in Distal Colon Mouse

Year: 2020

Type: article

Abstract: To date, PM literature as an anti-inflammatory treatment remains limited.In fact, there is a need for more studies on the pharmacological effects of PM.The authors then carried out an analysis of the PM extract.The extract used is known as the Phaleria macrocarpa Leaves Ethanol Extract (PMLEE).PMLEE is given to the colon tissue of mice, which has UC modeled with Dextran Sodium Sulphate (DSS).DSS is a pro-inflammatory agent generally believed to cause long-lasting inflammation.In addition, the Ki-67 protein was chosen as marker to determine PMLEE relationship with UC.This protein has a role in inflammatory process that can be assessed by immunohistochemistry. 11,12 Accordingly, the effect of PMLEE on UC could be defined by the measurement of Ki-67 expression.This study can provide insights into PMLEE's anti-inflammatory function and the basis for the development of PM as a possible alternative treatment for UC.

Source: Pharmacognosy Journal

DOI: 10.5530/pj.2021.13.56