Work

Collaborative Cross Founder Expression Analysis (CCFEA)

Year: 2021

Type: preprint

Abstract: To understand the role of host genetic variation in infection by SARS-CoV and influenza A virus we developed the Collaborative Cross Founder Expression Analysis (CCFEA), a shiny visualization tool using public RNAseq data from the collaborative cross (CC) founder strains (A/J, C57BL/6J, 129s1/SvImJ, NOD/ShILtJ, NZO/HILtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ) that underwent infection by either virus, linked with genetic analyses to define loci linked to infection, immunity, and disease phenotypes. Individual gene expression data is displayed across founders, viral infections and days post infection. Resource Table

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2021.03.04.422591

Authors: Richard R. Green, Reneé C. Ireton, Martin Ferris, Kathleen Muenzen, David R. Crosslin, Michael Gale

Institution: University of Washington

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases