Work

Investigation of EDTA concentration on the size of carbonated flowerlike hydroxyapatite microspheres

Year: 2021

Type: article

Abstract: Ethylenediamine tetraacetic acid (EDTA) is considered an effective crystal growth modifier for template-assisted hydrothermal synthesis of hydroxyapatite (HA) materials. In this work, flowerlike-carbonated HA (CHA) microspheres were synthesized using EDTA via a one-step hydrothermal route. The phase, functional groups, morphology and particle size distribution of the products were examined by X-ray diffraction, Fourier transform infrared spectrometer, field emission scanning electron microscopy as well as laser diffraction particle size analysis. Results show that the morphology of the products can be well controlled by adjusting the EDTA concentration. With an increase of the EDTA concentration, the particle size of flowerlike microspheres decreased from tens of microns down to a few microns. The underlying mechanism for the morphological transition of CHA microspheres with different concentrations of EDTA under hydrothermal conditions is proposed. This work provides a simple way to controllably fabricate CHA microspheres with various sizes using the same synthesis system for biomedical applications, such as cell carriers and drug delivery.

Source: Royal Society Open Science

DOI: 10.1098/rsos.202148

Authors: Shengkun Yao, Mei-li Qi, Liang Qi, Yongling Ding, Min Chen, Yanmin Wang

Institutions: Shandong Normal University, Shandong Jiaotong University

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,471

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation