Year: 2021
Type: review
Abstract: Since its discovery in 1994, leptin has been considered as an adipokine with pleiotropic effects. In this review, we summarize the actual information about the impact of this hormone on cartilage metabolism and pathology. Leptin signalling depends on the interaction with leptin receptor LEPR, being the long isoform of the receptor (LEPRb) the one with more efficient intracellular signalling. Chondrocytes express the long isoform of the leptin receptor and in these cells, leptin signalling, alone or in combination with other molecules, induces the expression of pro-inflammatory molecules and cartilage degenerative enzymes. Leptin has been shown to increase the proliferation and activation of immune cells, increasing the severity of immune degenerative cartilage diseases. Leptin expression in serum and synovial fluid are related to degenerative diseases such as osteoarthritis (OA), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Inhibition of leptin signalling showed to have protective effects in these diseases showing the key role of leptin in cartilage degeneration.
DOI: 10.3390/ijms22052411
Institutions: Instituto de Investigación Sanitaria de Santiago, Servicio Gallego de Salud, Universidad de Cantabria, Marqués de Valdecilla University Hospital, Instituto de Investigación Marqués de Valdecilla, Sun Yat-sen University, University Medical Center Utrecht, State Research Institute Centre for Innovative Medicine, The First Affiliated Hospital, Sun Yat-sen University, University of Oulu
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,160
Funders: European Federation of Pharmaceutical Industries and Associations, European Commission, Lietuvos Mokslo Taryba, Innovative Medicines Initiative, Xunta de Galicia, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Horizon 2020 Framework Programme, Research Executive Agency, Instituto de Salud Carlos III, Servicio Gallego de Salud, FP7 People: Marie-Curie Actions, Ministerio de Universidades
Awards: G1073258374, Chondrocyte ion channel function and regulation in health and disease, G1532936601, Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases, G1732308444, G177484282, G2325242462, G2393801413, G2488643646, G2557024270, G3207356259, Mechanotransdukciniai L tipo kalcio kanalai, kaip terapinis taikinys, veikiantis osteoartritinės kremzlės metabolinius procesus, G393177772, G3946622174, G4053127980, G4308038141, Adipokinas y E74-like factor 3 (ELF3): un nuevo circuito en las rutas de señalización de la respuesta inflamatoria en la degeneración del disco intervertebral., G4559066111, G4637685055, G4894445580, G4937468798, G5149053315, G5210856704, G5350679257, G5518805754, G5686640147, G5702163051, G6126592257, G6385464402, G654212923, Applied Public-Private Research enabling OsteoArthritis Clinical Headway, G6587516864, G6696204527, G6701547165, G6742565944, G682275100, Bioactive compounds from Olea europaea: investigation and application in food, cosmetic and pharmaceutical industry, G7722005679, G7868512380, G8448963523, G8824911526, Papel de las adipokinas en la degeneración del disco intervertebral (DDIV): un nuevo enfoque fisiopatológico
OpenAlex ID: W3134522652