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HIV, Cardiovascular Disease Risk Factors, and Subclinical Atherosclerosis among Kenyan Adults

Year: 2020
Type: dissertation
Study design: Observational Study
Abstract: carotid plaque, and mean CIMT, amongst the sub-cohort and then stratified by HIV status.Amongst PLHV, we examined the association between CIMT and HIV related factors, including viral load and CD4 count. ResultsThe HIV negative group had a higher prevalence of several traditional CVD risk factors including older age ≥ 55years (p =0.002), history of hypertension (HTN) (p=0.02),hypertension treatment (p = 0.03) and elevated blood pressure (BP) (p = 0.01).The overall mean CIMT in the cohort was 0.42mm (standard deviation [SD] 0.12), and lower in PLHV (0.41mm [SD 0.12] vs HIV negative (0.44mm [SD 0.14], p = 0.02).After adjustment for significant variables in the multivariable regression model, HIV status was not significantly associated with greater mean CIMT (p = 0.19).In the multivariable regression models, amongst PLHV, those with elevated blood pressure or hypertension treatment had a 0.06mm higher mean CIMT (95% confidence interval [CI]; 0.02,0.11,p = 0.002).In the HIV negative group, older age (0.07mm [95%CI; 0.02,0.12]p = 0.006), high total cholesterol (TC) (0.09mm[95%CI: 0.03,0.14]p = 0.01) and diabetes (0.17mm [95%CI:0.03,0.31] p= 0.02) were associated with higher mean CIMT.The overall prevalence of carotid plaque was low (15/262 [6.0%]), and not significantly different between the two groups (p =0.71).HIV related factors such as CD4 count, viral load, and ARV regimen were not associated with greater CIMT in the simple linear regression models. ConclusionWe found no significant association with HIV positive status and subclinical atherosclerosis.When stratified by HIV status, PLHV had fewer CVD risk factors associated with CIMT and HIV-related factors were not significantly associated with CIMT.
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W3135326239
Cites: 6
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Related to: 10