Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury: Potential Role of COL1A1 Variant
Year: 2021
Type: article
Study design: Observational Study
Abstract: PURPOSE: We aimed to investigate the hypothesis that type I collagen plays a role in increasing bone mineral density (BMD) and muscle stiffness, leading to low and high risks of fatigue fracture and muscle injury, respectively, in athletes. As a potential mechanism, we focused on the effect of the type I collagen alpha 1 chain gene (COL1A1) variant associated with transcriptional activity on bone and skeletal muscle properties. METHODS: The association between COL1A1 rs1107946 and fatigue fracture/muscle injury was evaluated in Japanese athletes. Effects of the polymorphism on tissue properties (BMD and muscle stiffness) and type I collagen α1/α2 chain ratios in muscles were examined in Japanese nonathletes. RESULTS: The C-allele carrier frequency was greater in female athletes with fatigue fracture than in those without (odds ratio = 2.44, 95% confidence interval [CI] = 1.17-5.77) and lower in female athletes with muscle injury than in those without (odds ratio = 0.46, 95% CI = 0.24-0.91). Prospective validation analysis confirmed that in female athletes, muscle injury was less frequent in C-allele carriers than in AA genotype carriers (multivariable-adjusted hazard ratio = 0.27, 95% CI = 0.08-0.96). Among female nonathletes, the C-allele of rs1107946 was associated with lower BMD and lower muscle stiffness. Muscle biopsy revealed that C-allele carriers tended to have a larger type I collagen α1/α2 chain ratio than AA genotype carriers (2.24 vs 2.05, P = 0.056), suggesting a higher proportion of type I collagen α1 homotrimers. CONCLUSION: The COL1A1 rs1107946 polymorphism exerts antagonistic effects on fatigue fracture and muscle injury among female athletes by altering the properties of these tissues, potentially owing to increased levels of type I collagen α1 chain homotrimers.
Authors: ERI MIYAMOTO-MIKAMI, HIROSHI KUMAGAI, KUMPEI TANISAWA, YUKI TAGA, KOSUKE HIRATA, NAOKI KIKUCHI, NOBUHIRO KAMIYA, RYOKO KAWAKAMI, TAISHI MIDORIKAWA, TAKUJI KAWAMURA, RYO KAKIGI, TOSHIHARU NATSUME, HIROFUMI ZEMPO, KOYA SUZUKI, YOSHIMITSU KOHMURA, KAZUNORI MIZUNO, SUGURU TORII, SHIZUO SAKAMOTO, KOICHIRO OKA, MITSURU HIGUCHI, HISASHI NAITO, NAOKAZU MIYAMOTO, NORIYUKI FUKU
Institutions: Juntendo University, Institute of Health and Sports Science & Medicine, Juntendo University, Juntendo Advanced Research Institute for Health Science, Waseda University, Shibaura Institute of Technology, Japan Society for the Promotion of Science, Nippon Sport Science University, Tenri University, J. F. Oberlin University, Josai International University, Tokyo Seiei College
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Awards: Influence of muscle stiffness and stretching effect on exercise-induced muscle damage, G3916067191, 高齢者の柔軟性の制限因子の解明および効果的なストレッチング方法の確立, Are differences in the capacity to oxidize fat associated with the risk of developing lifestyle-related diseases in middle-aged and older adults?, Elucidation of determinants of joint flexibility and establishment of custom-made stretching method to prevent muscle strains, Establishment of effective injury prevention programs for muscle strain, Identification of sport injury-related genetic polymorphisms in athletes, Effects of genetic polymorphisms on sport related injuries, Elucidation of genetic factors determining skeletal muscle and tendon characteristics, G6598595002, Assessing causal relationship of skeletal muscle- and fitness-related myokines with cardiometabolic risk factors, G821238054, Elucidation of genetic factors of muscle injury risk
OpenAlex ID: W3136090967