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Wasp Venom Biochemical Components and Their Potential in Biological Applications and Nanotechnological Interventions

Year: 2021
Type: review
Abstract: Wasps, members of the order Hymenoptera, are distributed in different parts of the world, including Brazil, Thailand, Japan, Korea, and Argentina. The lifestyles of the wasps are solitary and social. Social wasps use venom as a defensive measure to protect their colonies, whereas solitary wasps use their venom to capture prey. Chemically, wasp venom possesses a wide variety of enzymes, proteins, peptides, volatile compounds, and bioactive constituents, which include phospholipase A2, antigen 5, mastoparan, and decoralin. The bioactive constituents have anticancer, antimicrobial, and anti-inflammatory effects. However, the limited quantities of wasp venom and the scarcity of advanced strategies for the synthesis of wasp venom's bioactive compounds remain a challenge facing the effective usage of wasp venom. Solid-phase peptide synthesis is currently used to prepare wasp venom peptides and their analogs such as mastoparan, anoplin, decoralin, polybia-CP, and polydim-I. The goal of the current review is to highlight the medicinal value of the wasp venom compounds, as well as limitations and possibilities. Wasp venom could be a potential and novel natural source to develop innovative pharmaceuticals and new agents for drug discovery.
Source: Toxins
DOI: 10.3390/toxins13030206
Authors: Aida Abd El-Wahed, Nermeen Yosri, Hanem H. Sakr, Ming Du, Ahmed F. M. Algethami, Chao Zhao, Ahmed H. Abdelazeem, Haroon Elrasheid Tahir, Saad H. D. Masry, Mohamed M. Abdel-Daim, Syed Ghulam Musharraf, Islam El-Garawani, Guoyin Kai, Yahya Al Naggar, Shaden A. M. Khalifa, Hesham R. El-Seedi
Institutions: Agricultural Research Center, Menoufia University, Jiangsu University, Dalian Polytechnic University, University of Macau, Fujian Agriculture and Forestry University, Beni-Suef University, Riyadh Elm University, City of Scientific Research and Technological Applications, Suez Canal University, University of Karachi, International Center for Chemical and Biological Sciences, Zhejiang Chinese Medical University, Tanta University, Martin Luther University Halle-Wittenberg, Stockholm University, Uppsala University
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,113
OpenAlex ID: W3136529911
FWCI: 1.81
Cites: 175
Cited by: 83
Related to: 10