Work

c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

Year: 2021

Type: article

Abstract: Carcinogens trigger c-MYC-directed NRF2 activation. Over-activation of NRF2 promotes malignant progression of HNSCC through reprogramming G6PD- and TKT-mediated nucleotide biosynthesis. Targeting NRF2-directed cellular metabolism is an effective strategy for development of novel treatments for head and neck cancer.

Source: Theranostics

DOI: 10.7150/thno.53417

Authors: Ya-Chu Tang, Jenn-Ren Hsiao, Shih-Sheng Jiang, Jang-Yang Chang, Pei-Yi Chu, Ko-Jiunn Liu, Hsun-Lang Fang, Li-Mei Lin, Huang-Hui Chen, Yen-Wen Huang, Yu-Tsen Chen, Fang-Yu Tsai, Su-Fang Lin, Yung-Jen Chuang, Ching-Chuan Kuo

Institutions: National Health Research Institutes, National Tsing Hua University, National Cheng Kung University Hospital, National Cheng Kung University, Chang Bing Show Chwan Memorial Hospital, Min-Hwei College of Health Care Management, China Medical University

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

Funders: Ministry of Science and Technology, Taiwan, National Health Research Institutes

OpenAlex ID: W3136856597

FWCI: 4.905

Cites: 77

Cited by: 122

Related to: 10