Work

Regenerative cross talk between cardiac cells and macrophages

Year: 2021

Type: article

Abstract: Immediately postnatal mammalian hearts are able to regenerate after infarction, but the cells, pathways, and molecules that regulate this behavior are unclear. By comparing RNA-Seq datasets from regenerative mouse hearts and older, nonregenerative hearts, we are able to identify biological processes that are hallmarks of regeneration. We find that sterile inflammatory processes are upregulated in nonregenerative hearts, initiating profibrotic gene programs 3 days after myocardial infarction that can cause myocardial disease.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00056.2021

Authors: Alexander J. Whitehead, Adam J. Engler

Institutions: University of California San Diego, Sanford Consortium for Regenerative Medicine

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Achievement Rewards for College Scientists Foundation, National Institute on Aging, National Science Foundation Graduate Research Fellowship Program