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Molecular characterization of a Newcastle disease virus isolate from a diseased chicken in the Philippines in 2017

Year: 2021

Type: article

Abstract: Newcastle disease (ND) is one of the most serious diseases affecting numerous avian species worldwide.However, data on the genetic characterization of ND virus (NDV) in the Philippines are limited.Herein, the complete sequences of the fusion (F) and hemagglutinin-neuraminidase (HN) genes of a NDV strain isolated in Central Luzon in 2017 were genetically analyzed.The results revealed that the field isolate belonged to subgenotype VII.2 and the genome encoded the amino acid sequence of the F0 protein proteolytic cleavage site motif ( 112 R-R-Q-K-R-F 117 ), indicating that it was a virulent strain.The current NDV strain was genetically related to Indonesian and Israeli NDV strains.Some amino acid substitutions were found in the transmembrane domain and neutralizing epitopes of the HN protein.

Source: Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)

DOI: 10.14943/jjvr.69.1.73

Authors: Giang Thi Huong Tran, M. R. Mananggit, Lary N. B. Abao, Hieu Van Dong, Yohei Takeda, Haruko Ogawa, Kunitoshi Imai

Language: English

Topic: Virology and Viral Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: Obihiro University of Agriculture and Veterinary Medicine

OpenAlex ID: W3136983633

FWCI: 0.181

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Cited by: 2

Related to: 10