Year: 2020
Type: article
Abstract: Tissue-resident memory T cells (TRM) represent a heterogeneous T cell population with the functionality of both effector and memory T cells. TRM express residence gene signatures. This feature allows them to traffic to, reside in, and potentially patrol peripheral tissues, thereby enforcing an efficient long-term immune-protective role. Recent studies have revealed TRM involvement in tumor immune responses. TRM tumor infiltration correlates with enhanced response to current immunotherapy and is often associated with favorable clinical outcome in patients with cancer. Thus, targeting TRM may lead to enhanced cancer immunotherapy efficacy. Here, we review and discuss recent advances on the nature of TRM in the context of tumor immunity and immunotherapy.
DOI: 10.1084/jem.20201605
Authors: Karolina Okła, Donna L. Farber, Weiping Zou
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Awards: G1100779969, Novel immunosupressive macrophages in human ovarian tumor, G1404790370, G1425971015, G1457163447, Memory T Cells in the Tumor Microenvironment, G2106012746, G2108208586, G3213888141, G3296503969, G3713406226, G372229224, G378389786, Modeling the ecology of tissue-resident T cells, G4864279032, G6612995435, G7417736722, Metabolic impact on T cell-mediated cancer immunity and therapy, G8314757721, G9000014577, G9000030589, G9000031927, G9000073226, G9000148444, G9000152727, G9000154656, G9000176610, G9000321861
OpenAlex ID: W3138260539