Work

miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ

Year: 2021

Type: article

Abstract: In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1β and finally regulate the PPARγ pathway in BC. In conclusion, miR-22-3p/PGC1β suppresses BC cell tumorigenesis via PPARγ, which may become a potential biomarker and therapeutic target.

Source: PPAR Research

DOI: 10.1155/2021/6661828

Authors: Xuehui Wang, Zhilu Yao, Lin Fang

Institutions: Tongji University, Shanghai Tenth People's Hospital, Nanjing Medical University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,630