Year: 2015
Type: article
Abstract: In the course of discovering novel fungicidal lead compounds with high activity and safety, 13 new difluoromethyl substituted carboxamide derivatives were designed and synthesized according to the principle of bioactive substructure combination.Their structures were confirmed by 1 H NMR, MS and HRMS.The fungicidal activities of these compounds were evaluated.Preliminary bioassay showed that most of the title compounds showed good fungicidal activity at 200 mg/L.Keywords isoxazole; pyrazole amides; synthesis; fungicidal activity 杂环化合物由于其多变的结构和广泛的生物活性 使得在农药的开发中受到广泛的关注 [1～4] , 尤其是含氮 杂环化合物.吡唑酰胺类化合物作用机理独特、低毒, 吡唑环上的取代位点多, 取代位点的不同和取代基的不 同使该类化合物具有不同的生物活性, 已经成为农药研 究的热点之一 [5,6] .当吡唑 4 位上为酰胺取代基时往往表 现出杀菌活性 [7] , 其中含氟吡唑酰胺化合物由于结构新 颖、广谱高效和不同于现有杀菌剂的作用方式, 俨然预 示着杀菌剂开发的又一个新热点 [8] .最新报道的杀菌剂 中有 4 个都是以 3-二氟甲基-1H
Authors: Tingting Liu, Yun Ni, Liangkun Zhong, Hongying Huang, Weiqun Hu, Tianming Xu, Chengxia Tan
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W3141114360