Work

Inhibition of the DNA damage response to activate immune responses toward tumors

Year: 2021

Type: article

Abstract: Cancer immunotherapy represents a very encouraging mode of treatment for cancer where one's immune system is utilized to eliminate tumor cells. Wayne et al. explore inhibition of DNA damage response (DDR) pathways with small molecule inhibitors as a means to prime cells with immune response. These findings suggest that a one-size-fits-all approach cannot be used when harnessing immune response via DDR inhibitors and genotoxic agents, which are required ultimately for the success of immunotherapy. Comment on: https://doi.org/10.1111/febs.15747.

Source: FEBS Journal

DOI: 10.1111/febs.15836

Authors: Sheetal Sharma, Mrinal Srivastava

Institutions: Post Graduate Institute of Medical Education and Research, Tata Institute of Fundamental Research, TIFR Centre for Interdisciplinary Sciences

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W3141480656

FWCI:

Cites: 16

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Related to: 10