HIF-1α Inhibits Caspase 3 Mediated Apoptosis and Promotes Tumor Growth of Prostatic Carcinoma through Up Regulation of Cyclophilin A.
Year: 2020
Type: article
Study design: Observational Study
Abstract: Background:The management of prostate cancer may be difficult due to apoptosis resistance.HIF-1α (Hypoxia inducible factor 1α) and CypA (cyclophilin A) over expression promotes this resistance.Caspase 3 is a central executioner of the apoptosis pathway.Changed expression may correspond to tumor cell challenge.Aim: Evaluation of HIF-1α, CypA and Caspase 3 expressions in BPH (benign prostatic hyperplasia), PIN (prostatic intra-epithelial neoplasia) and PCa (prostatic carcinoma).Methods: One hundred four patients with histologically diagnosed prostatic carcinoma, 20 cases with BPH and 24 cases with PIN were investigated.Immunohistochemical assessment was executed to evaluate HIF-1α, CypA and Caspase 3 expressions.Results: In BPH cases, HIF-1α, CypA and Caspase 3 were expressed in 20%, 30% and 60% respectively.In PIN cases, HIF-1α, CypA and Caspase 3 were expressed in 33.3%, 41.7% and 41.7%, respectively while in PCa cases, HIF-1α, CypA and Caspase 3 were expressed in 57.7%, 69.2% and 25% respectively.Increasing stage of prostatic cancer showed a significant increased HIF-1α and CypA immunoexpression with lost caspase 3 immuno-expressions.Conclusions: Distorted HIF-1α, CypA and Caspase 3 expressions may act as a further mechanism of apoptotic resistance in prostatic carcinoma treatment.
Institution: Minia University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W3142312901