Treatment Volume, Dose Prescription and Delivery Techniques for Dose-intensification in Rectal Cancer: A National Survey
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND/AIM: The aim of the study was to investigate boost volume definition, doses, and delivery techniques for rectal cancer dose intensification. PATIENTS AND METHODS: An online survey was made on 25 items (characteristics, simulation, imaging, volumes, doses, planning and treatment). RESULTS: Thirty-eight radiation oncologists joined the study. Twenty-one delivered long-course radiotherapy with dose intensification. Boost volume was delineated on diagnostic magnetic resonance imaging (MRI) in 18 centres (85.7%), and computed tomography (CT) and/or positron emission tomography-CT in 9 (42.8%); 16 centres (76.2%) performed co-registration with CT-simulation. Boost dose was delivered on gross tumor volume in 10 centres (47.6%) and on clinical target volume in 11 (52.4%). The most common total dose was 54-55 Gy (71.4%), with moderate hypofractionation (85.7%). Intensity-modulated radiotherapy (IMRT) was used in all centres, with simultaneous integrated boost in 17 (80.8%) and image-guidance in 18 (85.7%). CONCLUSION: A high quality of treatment using dose escalation can be inferred by widespread multidisciplinary discussion, MRI-based treatment volume delineation, and radiation delivery relying on IMRT with accurate image-guided radiation therapy protocols.
Source: Anticancer Research
Authors: LUCIANA CARAVATTA, MARCO LUPATTELLI, GIOVANNA MANTELLO, MARIA ANTONIETTA GAMBACORTA, GIUDITTA CHILOIRO, MONICA DI TOMMASO, CONSUELO ROSA, LUCREZIA GASPARINI, ALESSIO GIUSEPPE MORGANTI, VINCENZO PICARDI, RITA MARINA NIESPOLO, MATTIA FALCHETTO OSTI, SABRINA MONTRONE, NICOLA SIMONI, CATERINA BOSO, FRANCESCA FACCHIN, MARIA ASSUNTA DEIDDA, CRISTINA PIVA, CESARE GUIDA, LUIGI ZICCARELLI, FERNANDO MUNOZ, GIOVANNI BATTISTA IVALDI, VANIA MARCHETTI, PAOLA FRANZONE, CORRADO SPATOLA, PIERFRANCESCO FRANCO, VITTORIO DONATO, DOMENICO GENOVESI
Institutions: University of Chieti-Pescara, Ospedale SS. Annunziata, University of Perugia, Azienda Ospedaliero-Universitaria delle Marche, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, University of Bologna, Regione Molise, Azienda Ospedaliera San Gerardo, Sapienza University of Rome, University of Pisa, Azienda Ospedaliera Universitaria Integrata Verona, Istituto Oncologico Veneto, Ospedale Civile Di Ivrea, Azienda Ospedaliera di Cosenza, Azienda USL della Valle d’Aosta, Istituti Clinici Scientifici Maugeri, Azienda USL Toscana Nord Ovest, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Turin, Azienda Ospedaliera San Camillo-Forlanini
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W3147586836