Year: 2021
Type: preprint
Abstract: Multi-scale models integrating biomolecular data from genetic, transcriptional, and translational levels, coupled with extracellular microenvironments can assist in decoding the complex mechanisms underlying system-level diseases such as cancer. To investigate the emergent properties and clinical translation of such cancer models, we present Theatre for in silico Systems Oncology (TISON, https://tison.lums.edu.pk ), a next-generation web-based multi-scale modeling and simulation platform for in silico systems oncology. TISON provides a “zero-code” environment for multi-scale model development by seamlessly coupling scale-specific information from biomolecular networks, microenvironments, cell decision circuits, in silico cell lines, and organoid geometries. To compute the temporal evolution of multi-scale models, a simulation engine and data analysis features are also provided. Furthermore, TISON integrates patient-specific gene expression data to evaluate patient-centric models towards personalized therapeutics. Several literature-based case studies have been developed to exemplify and validate TISON’s modeling and analysis capabilities. TISON provides a cutting-edge multi-scale modeling pipeline for scale-specific as well as integrative systems oncology that can assist in drug target discovery, repositioning, and development of personalized therapeutics.
Authors: Mahnoor N Gondal, Muhammad U Sultan, Ammar Arif, Abdul Rehman, Hira A Awan, Zainab Arshad, Waleed Ahmed, Muhammad FA Chaudhary, Salaar Khan, Zain B Tanveer, Rida Nasir Butt, Risham Hussain, Huma Khawar, Bibi Amina, Rida Akbar, Fatima Abbas, Misha N Jami, Zainab Nasir, Osama S Shah, Hadia Hameed, Muhammad FA Butt, Ghulam Mustafa, Muhammad M Ahmad, Sameer Ahmed, Romena Qazi, Fayyaz Ahmed, Omer Ishaq, Syed W Nabi, Wim Vanderbauwhede, Bilal Wajid, Huma Shehwana, Emad Uddin, Muhammad Safdar, Irfan Javed, Muhammad Tariq, Amir Faisal, Safee U Chaudhary
Institutions: Lahore University of Management Sciences, Duke University, University of Iowa, Shaukat Khanum Memorial Cancer Hospital and Research Center, University of Gujrat, National University of Computer and Emerging Sciences, University of Glasgow, University of Management and Technology, National University of Medical Sciences, National University of Science and Technology, National University of Science and Technology, National University of Sciences and Technology, Pakistan Institute of Engineering and Applied Sciences
Language: English
Subfield: Modeling and Simulation
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
Awards: G3456672709, G7748824640
OpenAlex ID: W3157634603