Work

Shikimic acid protects skin cells from UV-induced senescence through activation of the NAD+-dependent deacetylase SIRT1

Year: 2021

Type: article

Abstract: , suggesting that SIRT1 is a downstream effector of SA signaling specifically in the response to cellular senescence. Our study not only uncovers a shikimic acid/SIRT1 signaling pathway that prevents cellular senescence, but also reinforces the role of sirtuins as key regulators of cell proteostasis.

Source: Aging

DOI: 10.18632/aging.203010

Authors: Alfredo Martínez-Gutiérrez, Irene Fernández-Duran, Anna Marazuela-Duque, Nicolás G. Simonet, Ibraheem Yousef, Immaculada Martínez-Rovira, Josefina Martínez-Hoyos, Alejandro Vaquero

Institutions: Institut d'Investigació Biomédica de Bellvitge, Josep Carreras Leukaemia Research Institute, Mesoestetic Pharma (Spain), ALBA Synchrotron (Spain), Universitat Autònoma de Barcelona

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministerio de Ciencia, Innovación y Universidades, Ministerio de Economía y Competitividad, Agència de Gestió d'Ajuts Universitaris i de Recerca, European Regional Development Fund

Awards: G162362564, G3022609761, G6522933762

OpenAlex ID: W3159767445

FWCI: 2.329

Cites: 85

Cited by: 24

Related to: 10