Year: 2021
Type: article
Study design: Case Report
Abstract: We previously reported a 39-year-old man who presented with pulmonary and cerebral Cryptococcus gattii (genotype VGIIa) infection and was successfully treated with liposomal amphotericin B and flucytosine induction therapy. Following induction therapy, oral fluconazole treatment was initiated as consolidation therapy. However, the patient complained of progressively worsening headache, presenting an elevated cerebrospinal fluid (CSF) cell count. The minimum inhibitory concentrations of the CSF isolate were 8 and 0.12 μg/mL for fluconazole and voriconazole, respectively. The oral administration of voriconazole for more than 18 months alleviated his symptoms. Voriconazole might be useful for controlling refractory cases of C. gattii infection.
Source: Internal Medicine
Authors: Makoto Nakao, Kohei Fujita, Sousuke Arakawa, Shuntaro Hayashi, Saori Tomita, Hidefumi Sato, Hideki Muramatsu
Institution: Kainan Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Chiba University
OpenAlex ID: W3164841817