Pharmacokinetics of Polymyxin B in Hospitalized Adults with Cystic Fibrosis
Year: 2021
Type: article
Abstract: ). Although body weight was observed to influence the volume of distribution, a fixed dose of 75 mg every 12 h was predicted to achieve the target steady-state exposure. Neurotoxicities were reported in all patients, with acute kidney injury events in two patients. These events resolved within 2 to 4 days after discontinuing polymyxin B. Fixed maintenance dosing of polymyxin B without loading is predicted to achieve the targeted therapeutic exposure in CF adults. Treatment-limiting neurotoxicities are very common in this population.
DOI: 10.1128/aac.00792-21
Institutions: University of Michigan, Michigan Medicine
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Cystic Fibrosis Foundation
Award: G7381377108
OpenAlex ID: W3178411331