FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure
Year: 2021
Type: article
Abstract: loss skewed the specialization of lymphatic endothelial subsets, leading to populations with mixed, pro-fibrotic identities and to emergence of lymph node-like endothelial cells. Our study uncovers a cross-talk between lymphatic vascular function and commensal microbiota, provides single-cell atlas of lymphatic endothelial subtypes, and reveals organ-specific and systemic effects of dysfunctional lymphatics. These effects potentially contribute to the pathogenesis of diseases, such as inflammatory bowel disease, cancer, or lymphedema.
Source: Science Advances
Authors: Alejandra González-Loyola, Esther Bovay, Jaeryung Kim, Tania Wyss Lozano, Amélie Sabine, Francois Renevey, Silvia Arroz-Madeira, Alexis Rapin, Tomasz P. Wypych, Giorgia Rota, Stephan Durot, Dominique Velin, Benjamin Marsland, Greta Guarda, Mauro Delorenzi, Nicola Zamboni, Sanjiv A. Luther, Tatiana V. Petrova
Institutions: Ludwig Cancer Research, University of Lausanne, SIB Swiss Institute of Bioinformatics, École Polytechnique Fédérale de Lausanne, Monash University, ETH Zurich, Institute for Molecular Systems Biology, Centre Hospitalier Universitaire Vaudois, Institute for Research in Biomedicine, Università della Svizzera italiana
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,160
Awards: G1137844791, Cellular and molecular codes of organ-to-tumor communication, Metabolic programs of lymphatic endothelial cells and their disturbance in lymphedema, G4413229232, Deciphering the divergent roles of phosphatases in PD-1 and cytokine signaling, G4968863453, Signaling pathways controlling intestinal lymphatic vascular homeostasis and function, G5614230060, Therapeutic approaches for treatment of hereditary lymphedema, Fibroblasts of lymphoid tissues and their role in immunity, G6829068258, G8098773677, G8370645589, G8690818240
OpenAlex ID: W3182128200