Impact of tumor-infiltrating lymphocytes on pathological complete response after neoadjuvant chemotherapy in patients with early triple-negative breast cancer
Year: 2021
Type: article
Study design: Observational Study
Abstract: Description of the subject: Triple-negative breast cancer (TNBC), a breast cancer subtype, is characterized by the lack of both estrogen and progesterone hormonal receptors expression and by the absence of human epidermal growth factor receptor 2 overexpression.Patients with a pathological complete response (pCR) have better disease-free and overall survival compared to those with residual disease.The high level of tumorinfiltrating lymphocytes (TILs) is associated with a higher response to neoadjuvant chemotherapy (NAC) and better prognosis.Objective: Evaluation of TILs and their predictive impact in early TNBC in an Algerian population.Methods: We assessed TILs and correlated them with the pCR rate in 94 early TNBC patients treated from 2015 to 2017 who underwent breast microbiopsy, NAC, and then surgery.Results: Among 94 early TNBC patients, 53 (56.4%) achieved pCR and 41 (43.6%) had a residual disease.While some clinicopathological factors did not affect pCR, stromal TILs showed significant correlation with pCR (P < 0.0001).The presence of CD3 + , CD4 + , CD8 + and CD20 + TILs was also significantly correlated with pCR (P < 0.0001, P = 0.001, P = 0.0003 and P = 0.0001, respectively).Conclusion: Our data showed that TILs were significantly associated with pCR, suggesting that TILs are a predictive biomarker for pCR in early TNBC patients treated by NAC in our cohort. Key words: triple-negative breast cancer,
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3185017331