Work

Phosphorylation of the Inhibitor Component of Troponin by Phosphorylase Kinase

Year: 1972

Type: article

Abstract: Phosphorylase kinase catalyzes the phosphorylation of the inhibitor component (TNI) of troponin in the presence of ATP and Mgz+.Phosphorylation by nonactivated and activated phosphorylase kinase occurs at equal rates with a ratio of activity at pH 6.8 to 8.2 of 0.7.Measurements suggest that 1 mole of phosphate per mole of TN1 is bound after phosphorylation by phosphorylase kinase.Troponin, as isolated, contains endogenous protein-bound phosphate.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(19)44967-3

Authors: James T. Stull, Charles O. Brostrom, Edwin G. Krebs

Institution: University of California, Davis

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

OpenAlex ID: W31999413

FWCI: 18.28

Cites: 13

Cited by: 125

Related to: 10