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3-(imidazol-1-yl)propane-1,2-diol and 3-(1,2,4- Triazol-1-yl)propane-1,2-diol: Synthesis and Their Transformation to Bioactive Cyclic Ketals

Year: 2021

Type: article

Abstract: 3-(Imidazol-1-yl)propane-1,2-diol and 3-(1,2,4-triazol-1-yl)propane-1,2-diol were obtained by three alternative synthetic pathways such as hydrolysis of 1-[(1,3-dioxolan-4-yl)methyl]-azoles, Wagner reaction of N-allylazoles and reaction of glycidol with imidazole or 1,2,4-triazole.The 4-(azol-1-ylmethyl)-1,3-dioxolanes can be synthesized by reaction of 3-(imidazol-1-yl)propane-1,2-diol or 3-(1,2,4-triazol-1-yl)propane-1,2-diol with ketones to substituted 4azolylmethyl-1,3-dioxolanes

Source: RASAYAN Journal of Chemistry

DOI: 10.31788/rjc.2021.1436537

Authors: V.S. Talismanov, S.V. Popkov, O.G. Karmanova, S.S. Zykova, M.V. Shustov, L.A. Zhuravleva, N.G. Tokareva

Institutions: Moscow Institute of Physics and Technology, D. Mendeleyev University of Chemical Technology of Russia, Perm State Pharmaceutical Academy, Surgut State University, National Research Mordovia State University

Language: English

Topic: Synthesis and Reactions of Organic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W3201620025

FWCI: 0.479

Cites: 11

Cited by: 7

Related to: 10