Year: 2021
Type: review
Abstract: Ischemia and no obstructive coronary artery disease (INOCA) is an increasingly recognized cause of angina, and it is more commonly diagnosed in women. Coronary microvascular dysfunction (CMD), or the abnormal dilation and constriction of the small vessels of the heart, is the underlying cause of INOCA in one-half of cases. This review discusses coronary microvascular pathophysiology, considerations for invasive coronary function testing and noninvasive diagnostic modalities, implications for management, and remaining knowledge gaps.
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: Deutsches Krebsforschungszentrum, Society for Women’s Health Research, Cedars-Sinai Medical Center, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1764559527, G2026361351, G2058569893, Behavioral Medicine and Cardiovascular Research Training, EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR, G2933049717, EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR, ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CENTER, G3206908124, UCLA Clinical and Translational Science Institute, G3745418417, G3751788867, ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTER, Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF), UF Clinical and Translational Science Award, G4144345384, G4464624970, G461158050, Cardiovascular Events in Women's Ischemia Syndrome Evaluation, Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment, G6621596241, Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction, G7007650866, Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health, General Clinical Research Center, G7824414775, G8399618014, The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE), G8664061136, Cardiac Autonomic Function in Women, Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women, UCLA Clinical and Translational Science Institute
OpenAlex ID: W3202346554