Predictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group
Year: 2021
Type: article
Study design: Observational Study
Abstract: Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p < 0.0001; Cohen’s effect size = −0.519) was observed but not in controls (N = 124; from 98.87 ± 6.52 to 99.52 ± 2.15; p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p < 0.0001) and BDI-II (OR = 1.080; p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p < 0.0001) and VAFS-Mental (OR = 1.177; p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.
Source: Diagnostics
Authors: Diego Santos García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Lucía Naya Ríos, Lucía García Roca, Cristina Martínez Miró, Hector Canfield, Silvia Jesús, Miquel Aguilar, Pau Pastor, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Inés Legarda, Jorge Hernández Vara, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, María A. Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martínez Castrillo, Pilar Sánchez Alonso, Maria G. Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Marta Blázquez Estrada, Manuel Seijo, Javier Rúiz Martínez, Caridad Valero, Mónica Kurtis, Oriol de Fábregues, Jessica González Ardura, Ruben Alonso Redondo, Carlos Ordás, Luis M. López Díaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir, COPPADIS Study Group
Institutions: Complexo Hospitalario Universitario A Coruña, Complejo Hospitalario Universitario de Ferrol, Consejo Superior de Investigaciones Científicas, Biomedical Research Networking Center on Neurodegenerative Diseases, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, University Hospital Mútua de Terrassa, Hospital Clínic de Barcelona, Hospital de Sant Joan Despí Moisès Broggi, Hospital Universitario Son Espases, Vall d'Hebron Hospital Universitari, Complejo Hospitalario de Pontevedra, Hospital Universitario de La Princesa, Marqués de Valdecilla University Hospital, Hospital Clínico San Carlos, Hospital Militar Principal, Hospital de São Marcos, Hospital do Mar, Hospital Del Mar, Hospital Universitario Virgen Macarena, Hospital Universitario Infanta Sofía, Institut Català de la Salut, Institut d'Assistència Sanitària, Hospital General Universitario de Elche, Hospital Universitario Fundación Alcorcón, Hospital Universitari de Tortosa Verge de la Cinta, Hospital Universitario de Burgos, Hospital Universitario de Canarias, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramón y Cajal, Hospital Universitario Puerta de Hierro Majadahonda, University Hospital Complex Of Vigo, Complejo Hospitalario Universitario de Toledo, Complejo Hospitalario de Navarra, Hospital de Sant Pau, Hospital Universitario Central de Asturias, Donostiako Unibertsitate Ospitalea, Hospital Arnau de Vilanova, Hospital Ruber Internacional, Hospital Universitario De Cabueñes, Hospital Universitario Lucus Augusti, Complejo Hospitalario de Ourense, University of Pennsylvania
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,728
Funders: Sanofi, Biogen, Teva Pharmaceutical Industries, Fundación Mutua Madrileña, Fundación Alicia Koplowitz, International Parkinson and Movement Disorder Society, Jacques und Gloria Gossweiler-Stiftung, Ministerio de Economía y Competitividad, Sociedad Andaluza de Neurología, Junta de Andalucía, H. Lundbeck A/S, Italfarmaco, Allergan, Instituto de Salud Carlos III, European Regional Development Fund, UCB Pharma
OpenAlex ID: W3202468091