Work

Circulating extracellular vesicles of patients with steroid-sensitive nephrotic syndrome have higher RAC1 and induce recapitulation of nephrotic syndrome phenotype in podocytes

Year: 2021

Type: article

Abstract: Up to now, the role of extracellular vesicles (EVs) in the pathogenesis of steroid-sensitive nephrotic syndrome (NS) has not been studied. Here, we found that relapse NS EVs contain significantly increased active RAC1, induce enhanced podocyte motility, and increase expression of RAC-GTP and phospho-p38 expression in vitro. These results suggest that plasma EVs are biologically active molecules in the pathogenesis of NS.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00097.2021

Authors: Fehime K. Eroglu, Volkan Yazar, Ulku Guler, Muzaffer Yıldırım, Tugce Yildirim, Tulin Gungor, Evra Celikkaya, Deniz Karakaya, Nilsu Turay, Eda Ciftci Dede, Petek Korkusuz, Bekir Salih, Mehmet Bulbul, Ihsan Gursel

Institutions: Bilkent University, Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi, Sağlık Bilimleri Üniversitesi, Hacettepe University

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3202652983

FWCI: 1.502

Cites: 39

Cited by: 12

Related to: 10