Work

Sortilin as a marker of atherosclerosis: biological and pathophysiological aspects

Year: 2021

Type: article

Abstract: Subclinical atherosclerosis is an independent predictor of increased cardiovascular risk, including patients with hypertension. The article provides an overview of the pathogenetic role in atherogenesis and cardiovascular risk stratification of sortilin peptide which belongs to the family of vacuolar sorting receptors of type I. Circulating sortilin impacts both lipid and non-lipid pathogenetic mechanisms of atherogenesis. It can serve as an early biomarker of cardiovascular risk and a potential therapeutic target for dyslipidemia management and atherosclerosis at subclinical level.

Source: Arterial’naya Gipertenziya (Arterial Hypertension)

DOI: 10.18705/1607-419x-2021-27-4-402-408

Authors: I. V. Gubareva, Y. Y. Vukolova

Institution: Samara State Medical University

Language: English

Topic: Lipoproteins and Cardiovascular Health

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W3205267753

FWCI:

Cites: 56

Cited by: 1

Related to: 10